There is NO 100% safe amount of alcohol during pregnancy.

Fetal Alcohol Disorder May Be More Common Than Previously Thought

New Study by NIH: Fetal Alcohol Disorder May Be More Common Than Previously Thought

In a new JAMA study of more than 6,000 first-graders, researchers estimate that between 1.1% and 9.8% of American children have developmental or neurological problems caused by fetal alcohol spectrum disorders (FASDs)—a significantly higher number than previous studies have reported. And out of the hundreds of children determined in the study to have FASD, only two had been previously diagnosed.

The estimate comes from school-based assessments, family interviews and in-person evaluations of 6- and 7-year-olds in four communities across the country: one in the Midwest, one in the Rocky Mountains, one in the Southeast and one in the Pacific Southwest. Previous studies, which have estimated the rate of FASD to affect just 1% of children, involved smaller groups of people from single communities or from people in doctors’ offices, say the authors of the new study.

FASD is an umbrella term for health abnormalities caused by exposure to alcohol in the womb; it includes fetal alcohol syndrome, partial fetal alcohol syndrome and alcohol-related neurodevelopmental disorder. FASDs are a leading cause of developmental disabilities around the world, and people with these conditions can experience growth deficiencies, facial abnormalities and organ damage. They often have physical, cognitive and social challenges throughout life, and have an increased risk of premature death.

Before the current study began, researchers established standardized classification criteria for FASD based on facial features, growth, and neurodevelopmental performance. Using that criteria, they then screened a random sampling of first-graders in public and private schools in the four chosen regions, and interviewed the children’s mothers and other close relatives.

Based on their findings, the authors determined that FASD affected between 11 and 50 out of every 1,000 children they examined. That translates to between 1.1 and 5%, which they say is a conservative estimate: It assumes that no additional FASD cases would be found in children in those communities that hadn’t participated in the study.

When the researchers used a statistical technique assuming that the rate of FASD in children who were evaluated would be the same in all first-graders in those communities (more than 13,000 children total), the estimated FASD rate was even higher—ranging from 3.1% in the Southeastern group to 9.8% in the Rocky Mountain group.

The study provided additional evidence to suggest that FASD is currently underdiagnosed and underreported, as well: Of the 222 children whom researchers determined had FASD during the study, only two had been previously diagnosed. Many of these children’s parents and guardians were, however, aware of their learning and behavior challenges.

In their paper, the authors write that their prevalence estimates “are consistent with mounting evidence that harmful fetal alcohol exposure is common in the United States today.” To give the numbers some context, they note that autism—another common developmental disorder—is estimated to affect about 1.5% of children, which is comparable to the lower end of their FASD estimate.

The authors also cite a documented increase in alcohol use among women between 2001 and 2013, as well as a 2017 study in which 10% of pregnant women reported drinking alcohol (and 3% reported binge drinking) in the last 30 days.

The study was funded by the National Institutes of Alcohol Abuse and Alcoholism, and the classification criteria was created by the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence consortium, which studies FASD rates among U.S. school children. The study was co-authored by researchers from the University of California San Diego School of Medicine and the University of North Carolina.

It’s possible that the study’s estimates for alcohol-related neurodevelopmental problems were overestimated, the authors say, since there is no definitive biomarker for fetal alcohol exposure and no sure way to know that the developmental delays observed in the children were caused by their mothers’ drinking while pregnant.

And because the children in the study were from four specific geographic regions, the findings may not be generalizable to all communities in the United States. But the regions were chosen to make this study more nationally representative than previous ones, the authors say, and they believe their findings are likely to be more accurate, as well.

In an adjoining editorial, researchers from the University of Toronto write that the study’s conclusion—that FASD “is not a rare condition among the general U.S. population”—has substantial implications for both doctors and researchers. It not only suggests that many cases are missed or misdiagnosed, they say, but that additional support should be made available for those affected. More research and improved prevention programs are also needed, they add.

“The high prevalence of fetal alcohol spectrum disorders in the United States suggests better education of girls and women of childbearing age about the detrimental consequences of alcohol use during pregnancy on the fetus is needed,” the editorial states. “As suggested by the American Academy of Pediatrics, the message about alcohol use during pregnancy to the public should be clear and consistent: there is no safe amount, time, or type of alcohol to drink during pregnancy or when trying to get pregnant.”

Credit / Sources

This article was published by AMANDA MACMILLAN on February 6, 2018 by TIME Health. For more, visit TIME Health.

Key Points from JAMA Study

Question: How common are fetal alcohol spectrum disorders in the United States?

Findings: In this cross-sectional study of 13 146 first-grade children in 4 regions of the United States surveyed between 2010 and 2016, the most conservative prevalence estimate for fetal alcohol spectrum disorders ranged from 11.3 to 50.0 per 1000 children. Using a weighted approach, the estimated prevalence was 31.1 to 98.5 per 1000 children.

Meaning: These findings may represent more accurate US prevalence estimates than previous studies but may not be generalizable to all communities.

Source: Journal of the American Medical Association

What Does This Mean?

These estimates suggest that harmful levels of prenatal alcohol exposure are common in the U.S. today; they also highlight the public health burden due to FASD. A well-known developmental disorder, Autism Spectrum Disorders, is estimated to affect about 1.5% of children; our study suggests that FASD may be just as common as, and in some cases more common than, autism!

According to Dr. George Koob, the director of the National Institute on Alcohol Abuse and Alcoholism,

“Prenatal alcohol exposure is a leading preventable cause of developmental disabilities worldwide. Estimating the prevalence of FASD in the United States has been complex due to the challenges in identifying prenatally exposed children. The findings of this study confirm that FASD is a significant public health problem, and strategies to expand screening, diagnosis, prevention, and treatment are needed to address it.”

Read an editorial from the Journal of American Medicine (JAMA) on the implications of higher than expected prevalence of Fetal Alcohol Spectrum Disorders.

What are your thoughts?

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